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Health Talk: Chronic Myelogenous Leukemia


Normal blood vs. Leukemia

Normal blood vs. Leukemia

What Chronic Myelogenous Leukemia Is

Chronic Myelogenous Leukemia or CML is a type of a cancer affecting one’s blood cells and bone marrow. This condition is also called chronic myeloid or chronic granulocytic leukemia. Chronic myelogenous leukemia is an uncommon type of cancer of the blood cells, which progresses more slowly than acute forms of leukemia and affects older adults.

There are 3 phases of chronic myelogenous leukemia:
1) Chronic phase – this is the earliest phase which generally has the best response to treatment.

2) Accelerated phase – this is a transitional phase wherein the disease or condition gets aggressive.

3) Blastic phase  – this type of phase is the most severe and can be life-threatening.

How Is CML being diagnosed?

A series of laboratory tests is being performed to determine if a patient has CML. These tests are: 1) blood tests (complete blood count), 2) physical exam, 3) tests to look for Philadelphia chromosomes and 4) bone marrow tests (bone marrow biopsy and bone marrow aspiration).

What Are the Symptoms of Chronic Myelogenous Leukemia?

CML signs and symptoms may include the following: 1) fatigue , 2) weight loss, 3) loss of appetite, 4) pale skin, 5) night sweats, 6) fever , 7) easy bleeding and 8) pain or fullness below the ribs on the left side.

What Causes Chronic Myelogenous Leukemia?

There are several factors that possibly cause this type of condition: 1) development of an abnormal chromosome, 2) genetic mutation of abnormal chromosomes, 3) diseased blood cells created by the new gene

A human cell normally contains 23 pairs of chromosomes which hold the DNA that contains the instructions in controlling the cells in the body. In CML patients, chromosomes in the blood cells swap sections with each other wherein a section of chromosome 9 switch places with a section of chromosome 22, creating an extra short chromosome 22 (Philadelphia chromosome) and an extra long chromosome 9.

This Philadelphia chromosome then creates a new gene called BCR-ABL from the genes of chromosome 9 combined with genes from chromosome 22. This new gene contains instructions that command the abnormal blood cell to produce too much of a protein which we call tyrosine kinase, thus promoting cancer by allowing certain blood cells to go out of control.

A human blood cell originates in the bone marrow (a spongy material inside the bones). When a bone marrow functions normally, it produces immature cells in a controlled manner. These blood stem cells then mature and specialize into various types of blood cells circulating in a human body – red blood cells, white blood cells and platelets. In CML, this doesn’t work properly as the tyrosine kinase caused by BCR-ABL gene produces too many white blood cells which most, or all, contain the abnormal Philadelphia chromosome. The diseased white blood cells would build up in huge numbers, crowding out the healthy white blood cells and damaging the bone marrow.

Who  are at risk of CML?

There are 3 risk factors having this condition: 1) older age , 2) being a male, 3) exposure to radiation (e.g. radiation therapy) . Family history is certainly not a risk factor of this .

What Are Or Maybe The Possible Complications?

When left untreated, Chronic Myelogenous Leukemia may cause a variety of complications such as: 1) pain (bone or joint), 2) infection, 3) fatigue, 4) enlarged spleen and 5) death.


CML treatments such as Dasatinib (Sprycel), Imatinib (Gleevec), Ponatinib (Iclusig), Nilotinib (Tasigna) and Bosutinib (Bosulif) are designed to attack cancer by focusing on a specific type of cancer cells that allow them to grow and multiply. In CML, the target or goal of these drugs is the tyrosine kinase , a protein produced by the BCR-ABL gene.

Aside from these targeted drugs, there are also different treatments for CML like chemotherapy, biological therapy, blood stem cell transplant, clinical trials and even alternative medicines such as relaxation techniques, aromatherapy, massage, meditation and acupuncture

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got Chronic Myelogenous Leukemia? get to The National CML Society


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Compiled Recipe – Buckwheat Porridge with Mushrooms In A Crock Pot

Buckwheat Porridge with Mushrooms In A Crock Pot

* 2 cups (1/2 cup per crock pot) buckwheat
* 40 grams dried white mushrooms
* 4 slices boiled smoke brisket
* 4 cups water
* 4 eggs
* 4 tsp butter
* salt and pepper – to taste
* 4 individual crock pots

1) Rinse the buckwheat. Pour boiling water over the buckwheat and let it stand for over a few minutes, then drain the water. Cut the brisket and onion into fine pieces. Finely chop the mushrooms. Place equal proportions of mushrooms, onions, brisket, salt and pepper into each crock pot to taste. Evenly distribute the buckwheat into the crock pots, then fill with hot water in the amount needed to prepare the buckwheat.

2) Place in a pre-heated 180 degree oven. Cook in 3 stages:  1) 20 minutes at 180 degree, b) decrease the temperature to 160 degree and hold it at this temperature for 20 minutes, c) decrease the temperature again to 120 degrees and the buckwheat will be ready after 20 minutes.

3) Take the crock pots out of the oven. Break a raw egg over each of them and then briefly put them back in the oven. Once the egg whites harden, you can remove the pots from the oven again.

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Russian buckwheat kasha with mushrooms

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Compiled Recipe – Fried Oreo Cookies

Fried Oreo Cookies

* 125 grams flour
* 1 egg
* 1 tsp baking powder
* 250 mL milk (1 cup)
*Oreo cookies

1) Mix 125 grams flour, 1 egg, 1 tsp baking powder and 250 mL milk.

2) Dip the Oreo cookies into the mixture one at a time

3) Fry each Oreo cookie until brown. Top with refined sugar as garnish

*Note: Do not over mix as this will cause the mixture to become watery.



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Compiled Recipe – Brownies


* 250 grams caster sugar
* 180 grams plain chocolate drops
* 180 grams soft butter
* 110 grams plain flour
* 1 vanilla extract
* 3 eggs
* some butter for greasing
* 150 grams walnuts
* cooking spray

For decoration:
* melted white chocolate frosting
* melted chocolate frosting
* rainbow colored sprinkles
* red food coloring

1) Grease the side of the tin by rubbing with a kitchen towel dipped in a little soft butter. Line with a square of baking parchment or baking foil. Spray the baking foil using cooking spray.

2) Turn on the oven and set it to 160 degrees Celsius or 320 degrees Fahrenheit. Fill the saucepan with a little water and sit a heat proof bowl on top. The bottom of the bowl should not touch the water and not the bottom of the saucepan. Place butter pieces in the bowl and add the chocolate. Put the saucepan over a low heat. The butter and chocolate will gently melt over about 10 minutes. Don’t stir the chocolate mixture. When completely melted, stir gently with a wooden spoon. Turn off the heat, remove the bowl  from the pan, and leave it to cool.

3) Put the 3 eggs, 250 grams of sugar and 1 teaspoon of vanilla extract into a large bowl. Whisk together. Then add cooled chocolate mixture. Now add 110 grams of plain flour. Use the  cut and fold method to mix it. Add 150 grams chopped walnuts, as you like, then use the cut and fold method again to mix

4) Put the mixture in a tin and smooth the top over gently. Bake at 160 degrees Celsius for 20 to 30 minutes. Check after 20 minutes (note: the brownie should still be soft but not springy). Remove the brownie from the oven and leave it to cool in the tin for at least 30 minutes. Cut into squares with a  sharp knife. Use pallet knife to transfer the brownie to a serving plate.

5) Spoon the melted chocolate frosting over the cake pieces, then add red food coloring in melted white chocolate frosting and mix it well. Finally, decorate the brownie using white chocolate frosting and rainbow colored sprinkles and then serve.

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Compiled Recipe – Pelmeni With Onions and Mushrooms In Crock Pots

Pelmeni With Onions and Mushrooms In Crock Pots

* 500 grams pelmeni
* 1 onion
* 200 grams mushroom
* 200 grams sour cream
* 100 grams mayonnaise
*salt and pepper – to taste

For the pelmeni:
*300 grams flour
*200 grams of pork and beef (stuffing)
* 200 grams milk
* 1 egg
* 3 individual crock pots

1) For the stuffing: mix 150 grams of pork, 150 grams of beef and 1 onion in a meat grinder. Add salt and pepper to taste. Add 100 grams of milk. Mix the stuffing very well.

2) For the dough: Sift the flour and make a trough in it. Beat in an egg and stir. Add 100 grams of milk and salt. Knead the stiff dough and let it stand.

3) For the pelmeni:  Roll the dough into a thin layer that is 1.5 mm thick and cut out small circles that are 4 cm in diameter using a glass or cup. Place the stuffing in the middle of the circles and then pinch the edges, forming angular tips. Fry the mushrooms and onion in a pan. Fry the pelmeni in vegetable oil until they are golden brown.

4) For the sauce, mix sour cream and mayonnaise with water in a 1:1 proportion. Add salt and pepper as well as any of your favorite spices to taste. Grease the sides of the crock pots with butter in order to ensure that nothing sticks to the sides.

5) Add the ingredients in layers: add a layer of fried pelmeni to the bottom of the crock pot, then a layer of mushrooms and onions, followed by another layer of pelmeni, mushrooms and onions . Pour in the sauce until the pelmeni are completely covered.

6) Cover the crock pots and bake them for 30 minutes at 180 degrees.

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Food Review: Chop Stop

Craving for a pork dish  or any food that satisfies your hunger? You can check in at any Chop Stop branches near your location. You can try out their dishes such as Chops (Mushroom Gravy, Jack Daniel’s , Buffalo or BBQ) which comes along with Buttered Veggies or Nachos , Chomps (Bacon Quarterpounder, Meatball Spaghetti, Bacon & Eggs, Salisbury Steak and Fish Chops) and Chows (Buffalo Wings, Chows Platter, Bacon Cracklings, Cheesy Bacon Fries, Sour Cream Fries and Nachos). You can also order one of their desserts (choose from Red Velvet Mug Cake, Salted Caramel Milkshake,  Fudge Brownie Mud Cake and Oreo Milkshake).

We Love Chops

What I loved about Chop Stop is its design concept . You could see the traffic signs as its wall design. Perhaps, I could have taken a picture of its whole view. This was in Farmer’s Plaza, Cubao City.


What I tried during my visit here yesterday at Chop Stop is their BBQ Chops (pork).  This dish had just the right taste and you could also feel the crunchiness of its skin. I can’t help but love the savory sauce on this BBQ chops. Might as well try the other ones on my next visit here.



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Compiled Recipe – Donuts


* ½ cup unsalted butter
* 1/3 cup sugar
* 4 eggs
* 2 teaspoons yeast
* 1 teaspoon vanilla extract
* 4 cups flour
* salt
* 1 cup milk
* ¼ cup honey

For decoration:
* 1 cup powdered sugar
* 3 tablespoons milk
* 1 teaspoon vanilla extract
* 1 small drop pink food coloring
* sprinkles

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